Medizinische Fakultät

Universitätskliniken Inselspital

Department of Dermatology

Inselspital Bern

The Department covers the entire spectrum of dermatological diseases. In addition to clinical services and teaching, it conducts high-quality clinical and translational research focusing on the underlying immunological mechanisms of inflammatory and autoimmune skin diseases and the regulation of cytoarchitecture and cell integrity.

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Profile

  • Investigation of how T cell metabolism and T cell function are linked in inflammatory skin diseases
  • Investigation of the skin-specific cytokine interleukin 9 (IL-9) and its role in skin inflammation
  • Investigation of epithelial barrier dysfunction and type 2 inflammation
  • Translational and precision medicine studies in cutaneous T cell lymphoma
  • Dissect the autoimmune response in pemphigus with a focus on multi-omics characterization of the autoantibody-mediated tissue damage and skin blistering
  • A comprehensive systems biology approach to stem cell-mediated skin homeostasis implicating genetic, epigenetic, transcriptional, biochemical, and biophysical circuits
  • Investigation of bioelectricity to reduce stress, enhance wound healing, and harmonize skin homeostasis
  • Clinical trials with novel biologics and targeted therapies for atopic dermatitis, psoriasis, hidradenitis suppurativa, and melanoma
  • Deciphering the molecular mechanism of action of novel topical treatments for inflammatory skin disease
  • Investigating the role of upstream regulators of Th2 cells in atopic dermatitis
  • Analyzing the role of the cytokine interleukin 9 (IL-9) in skin inflammation

External Partners

Institute for Research in Biomedicine, Bellinzona; Huashan Hospital, Fudan University, Shanghai; Department of Immunology, University Hospital, Zurich; C.H.U. Henri Mondor, Paris; University Hospital, Düsseldorf; Universitätsklinikum Marburg; Institute of Molecular Systems Biology, ETH, Zurich; Centro Studi GISED, Bergamo; Lübeck Institute for Experimental Dermatology, University of Lübeck; Department of Information Technology and Electrical Engineering, ETH Zürich; Department of Dermatology and Cutaneous Biology, Thomas Jefferson University, Philadelphia; Department of Biomedical Engineering, University of California Irvine, CA, USA; The Regional Dermatology Training Centre, Tanzania

Grants

  • Ruth & Arthur Scherbarth Foundation: Role of PPAR-γ+ Th2 cells in allergic skin inflammation. CHF 100'000; 2021-2023
  • Swiss National Science Foundation (SNSF) Project grant: Unraveling the role of IL-9 in human skin inflammation; CHF: 700'000; 7/2020 – 06/2024
  • SNSF Synergia grant: Unravel Principles of Self-organization in Injured Tissue. CHF 2’943’631; 2021-2025
  • Private Donation R. Bolliger. CHF 463’000; 2021-2025